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Omega Cannon
The Omega Cannon is a powerful weapon capable of killing almost anything caught in the blast radius. It has been referred to by some as a "nuke-in-a-can" and "Weapon of Mass Destruction", although unlike nukes, it does not destroy the surrounding area. It just kills stuff. But it's still extremely powerful.
The Omega Cannon, or "OMG" for short, was created by the Alimbics, who locked it away within another dimension because they thought it was too powerful. Apparently, they had never seen a nuke. Only two people are known to have ever used the Omega Cannon: Samus Aran, who used it to kill a creature named Gorea, and Omegaman, who acquired it not long afterwards.